Charles A Dinarello Selected Research

Crohn Disease (Crohn's Disease)

1/2017	Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.
1/2007	Interleukin-18 and the pathogenesis of inflammatory diseases.
11/2005	IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
11/2005	Interleukin-18 treatment options for inflammatory diseases.
1/2005	Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease.
6/2003	Anti-cytokine therapeutics and infections.
4/2002	IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease.

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Charles A Dinarello Research Topics

Disease

148	Inflammation (Inflammations) 03/2024 - 01/2002
42	Neoplasms (Cancer) 12/2023 - 01/2002
36	Infections 01/2021 - 01/2002
20	Autoimmune Diseases (Autoimmune Disease) 02/2016 - 03/2002
19	Rheumatoid Arthritis 01/2020 - 03/2003
16	Colitis 01/2022 - 04/2006
13	Atherosclerosis 01/2020 - 01/2002
11	Heart Failure 01/2022 - 03/2003
11	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2020 - 06/2003
11	Fever (Fevers) 11/2020 - 03/2002
11	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2018 - 03/2004
10	Melanoma (Melanoma, Malignant) 12/2023 - 01/2003
9	Arthritis (Polyarthritis) 01/2021 - 09/2006
9	Gout 05/2020 - 12/2013
9	Sepsis (Septicemia) 02/2016 - 08/2002
8	Endotoxemia 01/2021 - 01/2002
8	Insulin Resistance 01/2020 - 06/2006
8	Necrosis 01/2017 - 11/2003
8	Disease Progression 04/2015 - 11/2002
8	Acute Kidney Injury (Acute Renal Failure) 12/2013 - 12/2004
7	Fibrosis (Cirrhosis) 01/2022 - 11/2002
7	Myocardial Infarction 01/2022 - 03/2003
7	Obesity 01/2018 - 06/2006
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2017 - 11/2003
7	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2017 - 01/2005
7	Crohn Disease (Crohn's Disease) 01/2017 - 04/2002
7	Ischemia 07/2016 - 06/2003
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 11/2005
6	Hyperglycemia 05/2013 - 06/2006
6	Neoplasm Metastasis (Metastasis) 06/2010 - 01/2003
5	Carcinogenesis 01/2019 - 09/2006
5	Fatigue 04/2017 - 12/2013
5	Macrophage Activation Syndrome 02/2016 - 11/2005
5	Type 2 Diabetes Mellitus (MODY) 12/2015 - 06/2010
5	Emphysema 06/2014 - 06/2013
5	Experimental Melanoma 04/2013 - 01/2003
5	Hepatitis 01/2007 - 01/2005
4	Neuroinflammatory Diseases 06/2023 - 08/2002
4	Pneumonia (Pneumonitis) 11/2020 - 02/2002
4	Left Ventricular Dysfunction 01/2018 - 01/2012
3	Virus Diseases (Viral Diseases) 11/2022 - 06/2011
3	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 11/2014
3	Asthma (Bronchial Asthma) 01/2022 - 01/2019
3	Weight Loss (Weight Reduction) 01/2022 - 06/2008
3	Leukemia 01/2021 - 03/2004
3	Peritonitis 01/2021 - 01/2019
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 12/2015

Drug/Important Bio-Agent (IBA)

127	CytokinesIBA 01/2023 - 01/2002
83	Interleukin-1 (Interleukin 1)IBA 11/2023 - 01/2002
54	Interleukin-18 (Interleukin 18)IBA 02/2024 - 03/2002
46	InterleukinsIBA 01/2023 - 02/2002
38	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2022 - 10/2003
32	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2022 - 02/2002
27	InflammasomesIBA 06/2023 - 02/2010
27	Proteins (Proteins, Gene)FDA Link 01/2023 - 04/2002
27	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2017 - 04/2002
19	Interleukin-6 (Interleukin 6)IBA 01/2021 - 03/2003
13	Histone Deacetylase InhibitorsIBA 01/2018 - 03/2004
11	Carrier Proteins (Binding Protein)IBA 06/2015 - 01/2003
10	Interleukin-1beta (Interleukin 1 beta)IBA 01/2022 - 08/2002
9	dapansutrileIBA 12/2023 - 01/2018
9	Interleukin-12 (IL 12)IBA 01/2019 - 04/2002
9	Messenger RNA (mRNA)IBA 01/2019 - 06/2010
8	Interferon-gamma (Interferon, gamma)IBA 03/2024 - 04/2004
8	Uric Acid (Urate)IBA 01/2021 - 01/2016
8	Interleukin-10 (Interleukin 10)IBA 01/2021 - 10/2003
8	Biomarkers (Surrogate Marker)IBA 11/2020 - 11/2005
8	ChemokinesIBA 07/2019 - 07/2002
8	Histone Deacetylases (Histone Deacetylase)IBA 10/2017 - 03/2002
8	LigandsIBA 01/2016 - 07/2002
6	Therapeutic UsesIBA 01/2021 - 12/2016
6	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2016 - 01/2004
5	Interleukin-33IBA 01/2022 - 09/2011
5	C-Reactive ProteinIBA 11/2020 - 03/2003
5	givinostat hydrochlorideIBA 01/2018 - 01/2005
5	Vorinostat FDA Link 10/2017 - 03/2004
5	Interleukin-1alpha (Interleukin 1 alpha)IBA 01/2017 - 03/2003
5	Peptides (Polypeptides)IBA 01/2017 - 05/2008
5	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2014 - 09/2006
5	matrigelIBA 04/2013 - 03/2003
4	Dexamethasone (Maxidex)FDA LinkGeneric 12/2023 - 09/2006
4	Dextran SulfateIBA 01/2022 - 04/2006
4	LipopolysaccharidesIBA 01/2021 - 03/2002
4	EnzymesIBA 09/2020 - 06/2003
4	Interleukin-8 (Interleukin 8)IBA 01/2020 - 10/2003
4	Protein Isoforms (Isoforms)IBA 01/2020 - 10/2014
4	canakinumab FDA Link 01/2020 - 12/2018
4	AlarminsIBA 01/2019 - 04/2014
4	Insulin (Novolin)FDA Link 01/2018 - 09/2003
4	Caspase 1 (ICE Protease)IBA 01/2016 - 04/2007
4	Serine Proteases (Serine Protease)IBA 01/2015 - 02/2006
4	AntibodiesIBA 04/2014 - 09/2004
4	Streptozocin (Streptozotocin)FDA Link 05/2013 - 11/2006
4	Small Interfering RNA (siRNA)IBA 02/2013 - 02/2008
4	p38 Mitogen-Activated Protein KinasesIBA 05/2009 - 06/2004
4	NF-kappa B (NF-kB)IBA 04/2009 - 06/2004
4	interleukin-18 binding proteinIBA 11/2008 - 11/2002
3	GlucocorticoidsIBA 12/2023 - 08/2005
3	Histones (Histone)IBA 01/2021 - 04/2006

Therapy/Procedure

41	Therapeutics 11/2023 - 01/2002